What Causes Nephrotic Syndrome
Many problems may cause nephrotic syndrome, together with ailments that have an effect on solely the kidneys and ailments that have an effect on many elements of the physique, resembling diabetes and lupus.
Illnesses that have an effect on solely the kidneys and result in nephrotic syndrome are referred to as major causes of nephrotic syndrome. The most typical major causes of nephrotic syndrome are3
Different causes of nephrotic syndrome, additionally referred to as secondary causes, include3
Signs You May Have Kidney Disease
More than 37 million American adults are living with kidney disease and most dont know it. There are a number of physical signs of kidney disease, but sometimes people attribute them to other conditions. Also, those with kidney disease tend not to experience symptoms until the very late stages, when the kidneys are failing or when there are large amounts of protein in the urine. This is one of the reasons why only 10% of people with chronic kidney disease know that they have it, says Dr. Joseph Vassalotti, Chief Medical Officer at the National Kidney Foundation.
While the only way to know for sure if you have kidney disease is to get tested, Dr. Vassalotti shares 10 possible signs you may have kidney disease. If youre at risk for kidney disease due to high blood pressure, diabetes, a family history of kidney failure or if youre older than age 60, its important to get tested annually for kidney disease. Be sure to mention any symptoms youre experiencing to your healthcare practitioner.
What Are The Complications Of Having Nephrotic Syndrome
Nephrotic syndrome can lead to serious complications, including2
- blood clots that can lead to thrombosis
- higher risk of infection caused by the loss of immunoglobulins, proteins in your blood that help fight viruses and bacteria
- brief or long-lasting kidney problems, including chronic kidney disease and kidney failure
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How Much Protein In The Urine Is Considered Excessive And Why
More than 3.5 grams of protein in the urine per day is considered excessive.
What is so special about losing 3.5 grams of protein every day?
That is the amount of protein lost when we know it is nephrotic syndrome. You can have protein in the urine from many different causes. However, nephrotic syndrome is the only condition that can result in this much protein in the urine.
The method of losing excessive amounts of protein due to nephrotic syndrome is fundamentally different from all other types of protein loss. To understand the difference, you need to imagine protein squeezing out of microscopic holes in your kidney filters. In essence, kidneys make up the filtration system of our blood.
In all other causes of protein loss, you can imagine smaller holes in the filter. The only proteins that spill out are the proteins small enough to squeeze out. Only proteins whose molecules are smaller than a certain size end up in the urine. This type of protein loss is selective. Important proteins that are heavier with bigger molecules are preserved. There are only so many small-sized proteins in the blood. Even when all the smaller proteins leak out, they wont amount to 3.5 grams a day.
How Do I Know If I Have Protein In My Urine
You can have a simple urine test. This is part of a routine exam. You will be asked to pee into a clean cup called a specimen cup. Only a small amount of your urine is needed to do the test. Some of the urine is tested right away with a dipstick a thin, plastic strip that is placed in the urine. The rest is looked at under a microscope and sent to a laboratory, where a test called an ACR is done. An ACR shows whether you have albumin in your urine. A normal amount of albumin in your urine is less than 30 mg/g. Anything above 30 mg/g may mean you have kidney disease, even if your GFR number is above 60.
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What Is Nephrotic Syndrome And How Does It Relate To Proteinuria
Nephrotic Syndrome is the name medical professionals give to a group of symptoms that suggest a serious kidney problem. Nephrotic Syndrome is not a disease, but a collection of symptoms that can be caused by any one of several diseases. Proteinuria is one of the most important signs that suggest a person could have Nephrotic Syndrome.
How Long Will I Have To Wait For A Transplant If I Need One
The process of getting listed for a kidney transplant often begins after you your evaluation. The average wait time for a kidney from a deceased donor is 3-5 years. If you have a donor who is willing and able to give you a kidney, you can have your transplant as soon as both you and your donor are ready. Learn more about the kidney transplant waiting list and what you can do while you wait.
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Can Diabetes Cause Protein In Your Urine
Should I be concerned about the presence of trace proteins in my urine? Proteins are substances that your body requires to function properly. Normally, protein is found in the blood. Protein can leak into your urine if you have a renal disease. While a trace of protein in the urine is normal, an abnormally high level may suggest kidney disease.
Will drinking water cause a decrease in the amount of protein in the urine? Unless you are dehydrated, drinking water will not resolve the reason of protein in your urine. Drinking water dilutes your urine , but it does not address the underlying cause of your kidneys leaking protein.
Is it possible for protein in urine to vanish on its own? What Is the Treatment for Protein in Urine? Proteins produced during an illness or fever will almost certainly resolve on their own. If your doctor determines that you have kidney disease, he or she will develop a treatment plan for you.
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If I Have Albuminuria Does It Mean I Have Kidney Disease
It may be an early sign of kidney disease, but your doctor will check you again to make sure albuminuria is not caused by something else, like not drinking enough water. If your doctor suspects that you have kidney disease, the test for albumin will be repeated. Three positive results over three months or more is a sign of kidney disease.
You will also be given a simple blood test to estimate GFR. GFR stands for glomerular filtration rate. Your GFR number helps determine how well your kidneys are working.
You may also be given:
Imaging tests. . This produces a picture of your kidneys and urinary tract. It can show whether your kidneys have kidney stones or other problems.
A kidney biopsy. This can help find out what caused your kidney disease and how much damage to the kidneys has happened.
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Further Tests For Nephrotic Syndrome
Sometimes, further tests may be required. These may include:
- ultrasound an examination of the kidneys using sound waves to outline the structure of the organs
- computed tomography scan uses x-rays and digital computer technology to create detailed two- or three-dimensional images of the internal organs and tissues
- magnetic resonance imaging uses a strong magnetic field and radio waves to provide clear and detailed pictures of internal organs and tissues.
What Are Clinical Trials For Nephrotic Syndrome
Clinical trialsand other types of clinical studiesare part of medical research and involve people like you. When you volunteer to take part in a clinical study, you help doctors and researchers learn more about disease and improve health care for people in the future.
Researchers are studying many aspects of nephrotic syndrome, such as
- the kidney diseases that can lead to nephrotic syndrome, including genes that may cause these diseases
- quality of life among people with nephrotic syndrome
- how to best treat nephrotic syndrome
Signs Of Kidney Disease
Protein In Urine Treatment
Proteinuria a sign of another illness. So treatment depends on figuring out what caused it. You might not need treatment if proteinuria is mild or lasts only a short time. But itâs crucial to treat kidney disease before it leads to kidney failure.
Your doctor might prescribe medication, especially if you have diabetes and/or high blood pressure. Most people will take one of two types of blood pressure medicine:
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How Will I Know If I Have Protein In My Urine
The only way to know if you have protein in your urine is to have a urine test. The test will measure the levels of protein in your urine.
The name of the urine test that measures the level of albumin in your urine is called the urine albumin-to-creatinine ratio . A UACR compares the level of albumin to the level of creatinine . A normal UACR is less than 30mg/g. If your UACR is 30 mg/g or higher, it can be a sign of kidney disease, and you should ask your doctor if you should have other tests of kidney disease.
If I Have Albuminuria Will I Need Treatment
If kidney disease is confirmed, your healthcare provider will create a treatment plan. You may also be asked to see a special kidney doctor called a nephrologist. Your treatment may include:
Lifestyle changes such as losing extra weight, exercising, and stopping smoking.
For more information:
Speak to your healthcare provider
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Urology Of Greater Atlanta
Protein in the urine may be a sign of serious health problems. To reduce protein levels, you need to tackle the problem that is causing the increase. The team of board-certified urologists at Urology of Greater Atlanta diagnose the cause of protein in urine and other conditions such as blood in the urine and provide appropriate treatment when necessary.
This article will cover why there may be a high level of protein in the urine, how it can be diagnosed, and what you can do about it.
What Are The Symptoms
The kidneys work hard to make up for the failing capillaries so kidney disease produces no symptoms until almost all function is gone. Also, the symptoms of kidney disease are not specific. The first symptom of kidney disease is often fluid buildup. Other symptoms of kidney disease include loss of sleep, poor appetite, upset stomach, weakness, and difficulty concentrating.
It is vital to see a doctor regularly. The doctor can check blood pressure, urine , blood , and organs for other complications of diabetes.
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How Do Doctors Treat Protein In The Urine
Doctors treat the cause of protein in the urine:
- If you have diabetes, your doctor will help create a treatment plan to keep it under control and slow down damage to your kidneys. They may recommend that you:
- Check your blood sugar often
- Take certain medicines
- Follow a diabetes-friendly eating plan
- Be active most days of the week
Drinking water will not treat the cause of protein in your urine unless you are dehydrated. Drinking water will dilute your urine , but will not stop the cause of your kidneys leaking protein.
If you have protein in your urine, talk with your doctor to choose the best treatment option for you.
How Can You Tell If There Is Protein In Your Urine
If you have kidney damage and protein is escaping into your urine, you may notice the following symptoms:
- Swelling in your face, abdomen or hands and feet.
- Urine that appears bubbly, foamy or frothy.
If you notice either of these symptoms, talk to your doctor about the cause and what the best treatment may be. In some cases, the issue will resolve on its own without further treatment.
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What Can Be Done If The Urinalysis Reveals Proteinuria With Signs Of Bleeding And Inflammation
If the urinalysis reveals inflammation or bleeding, your veterinarian may recommend further testing to look for conditions such as bacterial infection, bladder stones, prostatic disease , vaginitis , and cancer, etc. Following treatment, a repeat urinalysis is recommended to determine if the inflammation, bleeding, and proteinuria have disappeared.
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Whats The Ratio Of Albumin To Protein In Urine
A further reading centred on the ration of albumin to creatinine is made from analyzing your urine in the laboratory. The 24 hour urine protein creatinine ratio must not exceed 0.15. High levels of protein in urine are above 20mg/dL. They vary depending on the test that you are undergoing.
Protein in Urine Levels. Protein in Urine Normal Range. The protein in urine normal range is calculated in milligrams per deciliter. Protein in urine normal range is set at 20 mg/dL as the upper limit.
If a randomly collected sample shows a problem with the levels of protein in your urine, your doctor may want you to have the 24-hour urine test. Results from testing for proteinuria are classified into 24-hour urine analysis results and spot urine results.
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Is There Anything Else I Should Know
The different methods of detecting protein in the urine vary in performance. For example, a positive dipstick protein may be elevated due to other sources of protein, such as blood, semen, or vaginal secretions in the urine. Since it measures primarily albumin, the dipstick may occasionally be normal when significant quantities of other proteins are present in the urine.
A 24-hour urine sample gives the protein elimination rate over 24 hours. It will be accurate only if all of the urine is collected. The protein to creatinine ratio is more of a snapshot of how much protein is in the urine at the time the sample is collected. If it is elevated, then protein is present if it is negative, the amounts or the type of protein released in urine may not be detectable at that time.
Causes Of Protein In The Urine
Your kidneys, when working properly, filter waste products from your blood. They return protein and other materials that your body needs to function.
Some conditions and diseases can cause the level ofprotein in your urine to rise. Short term conditions that cause protein in the urine can include strenuous exercise, fever, heat or cold exposure and emotional distress. Long term conditions and diseases that can lead to protein in the urine include high blood pressure, kidney infection or disease, heart disease, diabetes, lupus and malaria.If a urine test reveals protein in your urine, your doctor may recommendfurther testing to determine the cause. Test may include a 24-hour urine collection to determine whether the protein in your urine is cause for concern. Your doctor may also follow up with an ultrasound or CT scan to look for issues like kidney stones or a biopsy to see what has caused damage to your kidneys.
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