Normal Range Protein In Urine

Analysis Of Urine Protein Components

Urine Protein Cause, and Proteinuria Normal Range and Treatment

Urine protein can be separated into albumin and gamma globulin fractions. Measurements of urinary albumin excretion by radioimmunoassay can pick up larger amounts than normally would be detected. These are not generally clinically helpful, although diminution in albumin excretion correlates with clinical response to treatment. Microalbuminuria is associated with mesangial disease and does not predict the development of nephritis, whereas polymeric albumin is associated with more serious disease. Urinary protein electrophoresis demonstrates increased gamma globulin levels during active disease levels decrease with therapeutic response. No specific patterns are observed in patients with SLE.2

Robert W. Hunter, … Matthew A. Bailey, in, 2020

What Are The Normal Protein Levels In Urine

Protein levels are also frequently mentioned in urine test, which can be an indicator of the urination health. Tiny amounts of protein are typically in our urine however, most tests will not detect these tiny amounts, as they cause no harm. However, some dipstick tests will spot kidney problems and other maladies that are indicated by higher or lower than normal protein levels. Some common issues, such as pregnancy, fever, and extensive exercise, can lead to more than normal protein in the urine.

Urine Test

This test is extremely simple. It requires a sample of urine in a cup, which is then tested by dipping a special ‘stick’ or paper tab into the urine. The test results are usually available within minutes and will tell you what your protein levels are. For a more extensive test, your doctor might ask you to collect your urine over a 24-hour period.

Normal values of protein in urine are typically between 0 and 20 mg/dL. For the 24-hour collection, anything below 80 mg/dL is considered normal. Again, remember that the range might vary, depending upon the laboratory used.

What Abnormal Results Mean

High amounts of protein in the urine might mean heart failure, kidney damage, severe dehydration, urinary tract infections or tumors, as well as problems with a current pregnancy, such as preeclampsia. A high urine protein result usually means that your doctor will go one step further and test your blood for normal protein levels.

Possible Treatment

Normal Values Of Protein In The Urine

Proteins are an important part of our body, since they are responsible for making up many different types of substances and cells and, therefore, they fulfill a wide variety of functions in the body. Many of these functions are carried out in the bloodstream, such as albumin, which has as one of its main functions serving as a means of transporting hormones, fats, drugs and many other substances, which adhere to it. To travel through the blood

Proteins, once they have fulfilled their functions and are no longer useful for us, are discarded through the urine, so the study of the protein values in our urine is a valuable element for the evaluation of the condition of Our organism. In this FastlyHealarticle we will talk about normal values of protein in the urine , a test that is usually done as a routine for the diagnosis of many diseases.

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Testing For Urine Protein

If your kidneys are functioning normally, you should have almost no detectable protein in your urine 2.Several common laboratory tests are used to check for proteinuria, including urine dipsticks for quick screening purposes, automated instruments for a more sensitive measurement of total protein and 24 hour urine collections to look for protein loss over time 12. Although results can vary somewhat between different laboratories, the amount of protein in a random sample of urine is normally less than 8 mg/dL and for a 24-hour collection, less than 150 mg total, according to MedlinePlus 2.

How To Interpret The Test Result

Protein Levels In Urine Normal Range

A negative test result means that there is no detectable amount of protein in the urine at the time of testing.

When the test is positive several factors needs to be considered.

  • Rule out for the normal conditions which can cause transient elevation of protein levels. They include pregnancy, emotional stress
  • Exclusion of the normal conditions can be done by repeat testing over a period of time especially after the conditions are resolved.
  • The presence of 3 positive test results over a period of time is considered as significant and needs to be evaluated further with additional tests which include 24-hour urine.

Persistent and/or an increased amount of protein in the urine may indicate kidney damage or disease. With kidney disease, the amount of protein present is generally associated with the severity of the damage. Increasing amounts of protein over time indicate increasing damage and decreasing kidney function.

Disorders with increased urine protein.

  • Urinary tract infection

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What Are Normal Protein Levels In Blood

When you take blood test, the results will tell you several things. The amounts of albumin in your blood will reveal whether you have a healthy diet, help determine the causes of swelling in various areas of your body, and let you know if your kidneys and liver are working properly. Testing on globulin levels will determine your chances of an infection, as well as spot any blood diseases you might have, such as multiple myeloma and related problems.

Total Protein Test

Also known as a total serum protein test, this blood test will help determine whether you have normal protein levels. It is done with a simple blood draw the technician will use a tourniquet to slow the blood flow to your arm then will insert a needle into the vein. They will then fill up a tube of blood for testing. Some people say that the testing is uncomfortable, while others barely notice any discomfort at all. Either way, the test is over quickly. Your blood sample is then sent to a lab for analysis.

Normal Protein Level in Blood

When the report is ready, it will give you several numbers. It is important to note what the lab considered normal protein levels. There is a range of what is considered normal. Most labs will consider anything between 6.4 and 8.3 grams per deciliter to be normal for a total protein count. However, normal range depends upon the lab, and could include numbers higher or lower than these. Here is a chart that reveals details of total protein test.

Abnormal Protein Level in Blood

Normal Protein Levels In Urine

Normally, negligible amount of protein is present in urine. Read on to know the causes of high protein in urine. The article also explains how to lower protein in urine. Scroll down.

Normally, negligible amount of protein is present in urine. Read on to know the causes of high protein in urine. The article also explains how to lower protein in urine. Scroll down.

To measure the amount of protein in urine, a random sample and/or a 24-hour urine sample is used. The test that helps measure the protein content of urine is known as dipstick test. Presence of a protein like albumin in urine mainly indicates kidney problem. This condition is known as proteinuria or albuminuria or urine albumin. Albumin is actually abundantly present in blood. Proteins, the building blocks of the body are necessary to strengthen the cellular function, muscles, bones, hair and nails. Proteins strengthen the immune system and help keep away diseases. Losing protein through urine can lead to several health complications.

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Measurement Of Urine Albumin

As in other parts of the world, routine measurement procedures for urine albumin in Australasia are predominantly immunoassay-based, mostly immunoturbidimetric. Work done by Comper and colleagues6 in 2002 suggested that immunoassay methods might significantly underestimate albumin, particularly in diabetic patients. However, subsequent work questioned the definitive resolution of albumin by the HPLC method used.7 Not all immunoassays perform equally and whether modified albumin is measured appears to depend on assay design, in particular whether polyclonal or monoclonal antibodies are used. Albumin has at least five antigenic sites and studies using polyclonal antibodies in a competitive assay design have been shown to measure some modified forms as well as non-human forms of albumin.8

While standardisation is clearly important, the major cause of variation in urine albumin measurement occurs outside the analytical process and much can be done to improve practice in both the pre- and post-analytical phases. Important pre-analytical factors are listed in Table 1 the post-analytical phase is beyond the scope of this article.

Detecting And Quantifying Proteinuria

How To Lower Protein in urine, Proteinuria & Improve Kidney Health & Kidney Function

Dipstick evaluation is utilized in most outpatient settings to semiquantitatively measure the urine protein focus. Within the absence of protein, the dipstick panel is yellow. Proteins in resolution intrude with the dye-buffer mixture, inflicting the panel to show inexperienced. False-positive outcomes happen with alkaline urine when the dipstick is immersed too lengthy with extremely concentrated urine with gross hematuria within the presence of penicillin, sulfonamides or tolbutamide and with pus, semen or vaginal secretions. False-negative outcomes happen with dilute urine and when the urinary proteins are nonalbumin or low molecular weight.

The outcomes are graded as unfavorable , hint , 1+ , 2+ , 3+ or 4+ . This technique preferentially detects albumin and is much less delicate to globulins or components of globulins .12

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How To Treat Proteinuria

Being diagnosed with proteinuria is disheartening. It is however not life threatening. With proper management, proteinuria will go away. You will need to implement some lifestyle changes. These will include better diet management. You will also be asked to stop smoking, drinking alcohol, and lose excess weight.

Medication may be given in the course of treating your proteinuria. Only use drugs prescribed by your doctor and approved for treatment of proteinuria. Follow the dosage of such medication faithfully.

A number of health problems can lead to proteinuria. They include high blood pressure, infections, drugs, diabetes and mediation, tumors such as multiple myeloma and kidney disease, Mild proteinuria is not indicative of a serious disorder. Nevertheless, elevated amounts of protein in your urine are not considered normal. Persistently high protein levels in urine outside the protein in urine normal range is often a sign of improperly functioning kidneys.

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How The Test Is Performed

After you provide a urine sample, it is tested. The health care provider uses a dipstick made with a color-sensitive pad. The color on the dipstick tells the provider the level of protein in your urine.

If needed, your provider may ask you to collect your urine at home over 24 hours. Your provider will tell you how to do this. Follow instructions exactly so that the results are accurate.

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Is There Anything Else I Should Know

The different methods of detecting protein in the urine vary in performance. For example, a positive dipstick protein may be elevated due to other sources of protein, such as blood, semen, or vaginal secretions in the urine. Since it measures primarily albumin, the dipstick may occasionally be normal when significant quantities of other proteins are present in the urine.

A 24-hour urine sample gives the protein elimination rate over 24 hours. It will be accurate only if all of the urine is collected. The protein to creatinine ratio is more of a snapshot of how much protein is in the urine at the time the sample is collected. If it is elevated, then protein is present if it is negative, the amounts or the type of protein released in urine may not be detectable at that time.

Screening For Kidney Disease

Protein In Urine

Although urine protein measurement can be used to assist in the diagnosis of kidney disease and to assess disease progression and response to therapy , it is most commonly used as a screening test. Microalbuminuria is defined as urine albumin excretion of 30 to 300 mg/day and appears to be an important risk factor for end-organ damage in patients with diabetes or hypertension. Most studies showing a relationship between microalbuminuria and end-organ damage have used 24-hour quantitative techniques to measure urine albumin excretion. As previously discussed, this is cumbersome and prone to error, and an albumin/creatinine ratio in an untimed spot urine specimen can be used instead. Indeed, albumin/creatinine ratios have been shown to predict the subsequent development of overt kidney disease. A value above 30 mg/g suggests that albumin excretion is above 30 mg/day, consistent with microalbuminuria.

Sharon I. Maynard, Ravi E. Thadhani, in, 2015

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How Is Proteinuria Treated

Treatment depends on the underlying condition that caused proteinuria. Each condition requires different treatments.

If kidney disease is confirmed, a treatment plan might include medication, diet changes, weight loss and exercise. Diabetes and hypertension patients with proteinuria might need blood pressure medication, and those with diabetes will have to control their blood sugar. Diabetes patients should receive glomerular filtration rate blood tests every year and may be referred to a nephrologist, a doctor who specializes in the kidneys.

Pregnant women with preeclampsia should be watched carefully. The condition, although serious during pregnancy, usually resolves itself once the baby is born. Proteinuria patients with low blood pressure should schedule annual urine tests and blood pressure checks.

If proteinuria isnt accompanied by diabetes, high blood pressure or any other medical condition, blood pressure medication still might be prescribed to prevent kidney damage. Blood pressure and urine should be checked every six months to make sure kidney disease isnt present. As for those with mild or temporary proteinuria, treatment may not be necessary.

Standardisation Of Urine Albumin Measurement

Standardisation of urine albumin is required because currently common decision limits are used and it is likely that misdiagnosis occurs as a result of differences in calibration. As well, evidence suggests that risks are continuous variables commencing at levels below the current lower limit for microalbuminuria.1 Standardisation requires a primary reference system comprising a defined measurand, measured against an appropriate reference material that is value assigned by a reference measurement procedure and, to date, none of these components has been confirmed. In 2007, the National Kidney Education Program and the IFCC formed a joint committee whose objective is to co-ordinate the creation of such a system and to standardise the laboratory components such as sample collection and result reporting.2

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What Do My Test Results Mean

Your urine test procedure results may not mean anything normally. The urine protein normal range for a urine routine examination is 50mg to 80mg for sedentary patients while less than 250mg is considered normal within a 24-hour period for those who have exercised before taking the test.

You should talk to your doctor regarding what your test results indicate after you get your report or if you want to learn how to reduce protein in urine.

When To Get Tested

Protein in Urine (Proteinuria) | Causes and Symptoms | Urinox-10

As part of a routine physical, often as part of a urinalysis urine total protein and urine protein to creatinine ratio have traditionally been used as important indicators of kidney disease and as a follow-up testing for monitoring the disease. However, albumin to creatinine ratio is now the preferred testing for these purposes.

UPCR should still be requested to identify preeclampsia in pregnant women and where the excess urine total protein is suspected to be other than albumin.

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Measurement Of Total Protein In Urine

Measurement of total protein in urine has a number of limitations as a screening tool for proteinuria. Different methods may react disproportionately for each protein present in a given urine sample making standardisation impossible.15 There is no universally accepted definition of proteinuria with normal varying from < 150 to < 300 mg/L and 23 to 100 mg/mmol creatinine. As well, urine total protein measurement is less robust at low levels of protein than is urine albumin measurement and it is insufficiently sensitive to detect all clinically important concentrations of urine albumin.16 Some authors have even questioned the commonly held view that screening using urine albumin alone would miss tubular proteinuria.17

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What Do The Test Results Mean

Test results should be available after a couple of days, depending on the lab schedule. A normal test result shows less than 150 milligrams of protein per day. Test results may vary slightly between laboratories. Ask your doctor about the exact meaning of your test results.

Protein in the urine may signify kidney damage or disease. Protein levels may also rise temporarily due to factors such as infection, stress, or excess exercise.

If the protein is caused by kidney damage, the test results will help to determine the extent of that damage. The protein amount can also be used to monitor any disease progression or measure your response to therapy.

Proteinuria is associated with many other conditions. These include:

  • amyloidosis, an abnormal presence of amyloid proteins in organs and tissues

If I Have A Positive Urine Protein Test What Other Tests Might Be Done In Follow Up

Urine protein level during pregnancy

A positive urine protein test tells your healthcare practitioner that protein is present in your urine, but it does not indicate which types are present or the cause of the proteinuria. When investigating the reason, your health care practitioner may order additional laboratory tests, such as:

  • Comprehensive metabolic panel includes tests such as BUN, creatinine, albumin and total protein, which help evaluate kidney and liver function
  • A full urinalysisif a condition such as urinary tract infection is also suspected
  • Serum and urine protein electrophoresis testto determine which proteins are being released into the urine and in what quantities this is especially true if your health care practitioner suspects abnormal monoclonal protein production, such as with multiple myeloma or lymphoma.

If kidney disease or damage is suspected, your healthcare practitioner may also order imaging scans to evaluate the appearance of your kidneys.

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