How To Reduce C Reactive Protein

Study Supplements And Allocation

High C-reactive Protein: How To Reduce CRP Level? | Practo #Shorts

Participants were assigned to one of three different treatment groups using blocked, stratified randomization, and a randomization sequence of letters of the alphabet representing treatment groups was generated by computer program. Randomization was stratified by gender, weight , and either menopausal status for women, or age for men. Lettered bottles containing treatment components were provided to participants by clinical staff unaware of treatment allocation. The three treatment arms were 1) vitamin C tablet and placebo capsule 2) vitamin E capsule and placebo tablet and 3) placebo tablet and placebo capsule. Placebo tablets contained lactose, microcrystalline cellulose, and small amounts of stearic acid, magnesium stearate, and croscarmellose sodium. Placebo capsules contained medium consisting of lecithin and soybean oil. Vitamin C tablets and vitamin E capsules were indistinguishable from placebo tablets and capsules. Study supplements and placebo pills were provided by Pharmavite, LLC . Investigators, clinic and laboratory staff and participants were masked to treatment assignment. Separate study staff administered the intervention and analyzed data.

And The Herbal Supplement Ginseng May Be Effective At Doing Just That

Researchers at the Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran did this review of human research.

The journal Complementary Therapies in Medicine published the results.

Ginseng has a number of potent anti-inflammatory effects.

Because of this, many researchers have proposed that ginseng may lower CRP.

But human research has provided conflicting results.

These researchers analyzed information from many different human studies to get a better understanding of ginsengs effect on CRP.

The researchers identified seven high-quality human studies for analysis. Some of these studies involved more than one experiment.

They combined all of the information gathered in these studies.

Extra Virgin Olive Oil

A big part of the Mediterranean diet, extra virgin olive oil has many health benefits, including reducing the inflammation that leads to heart disease. One study found that when people got about 3 tablespoons of this oil each day, levels of C-reactive protein , a measure of inflammation in the body, dropped significantly.

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What Does The Test Result Mean

Relatively high levels of hs-CRP in otherwise healthy individuals have been found to be predictive of an increased risk of a future heart attack, stroke, sudden cardiac death, and/or peripheral arterial disease, even when cholesterol levels are within an acceptable range.

People with higher hs-CRP values have the highest risk of cardiovascular disease and those with lower values have less risk. Specifically, individuals who have hs-CRP results at the high end of the normal range have 1.5 to 4 times the risk of having a heart attack as those with hs-CRP values at the low end of the normal range.

The American Heart Association and U.S. Centers for Disease Control and Prevention have defined risk groups as follows:

  • Low risk: less than 1.0 mg/L
  • Average risk: 1.0 to 3.0 mg/L
  • High risk: above 3.0 mg/L

These values are only a part of the total evaluation process for cardiovascular diseases. Additional risk factors to be considered are elevated levels of cholesterol, LDL-C, triglycerides, and glucose. In addition, smoking, high blood pressure , and diabetes also increase the risk level.

What Is Considered A High Crp Level

CRP Blood Test

Anything above 10 mg/L, or a minor elevation, may be considered a high CRP level. Generally, a CRP reading greater than 10 mg/L is considered dangerous, saysDaniel Boyer, MD, researcher at the Farr Institute in West Des Moines, Iowa. It is likely caused by a severe bacterial infection and indicates acute inflammation that requires further tests to determine the cause of the inflammation.

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The Advent Of Molecular Biology Ushered In A Deeper Understanding Of C

Figure 1 C-reactive protein is a pentamer with two distinct faces. On the A face each CRP monomer displays an -helical stretch of residues adjacent to the C1q and FcR binding sites and on the opposite B face each monomer displays residues that help coordinate two Ca2+ ions that assist with binding to ligands . The image is a reproduction of structure 1B09 as reported by and was created using NGL accessed on PDB .

Figure 2 The human C-reactive protein gene. Downstream of CRP is the CRP pseudo-gene , that is likely involved in cis-acting regulation of basal CRP expression. The proximal promoter of CRP is typically mapped as the region ~300 nucleotides upstream of the transcription start site, including the TATA binding site at 29 to 26 . The short 5 untranslated region precedes the coding sequence for the 18 amino acid-long leader peptide . Exon 1 encodes the first three amino acids of mature CRP and is immediately followed by the intron. The remainder of CRP is encoded by exon 2 . CRP has a long 3UTR sequence with a poly signal . Each region is drawn approximately to scale. The relative locations in the CRP promoter of binding elements for hepatic nuclear factor 1 and HNF3 that contribute to regulation of constitutive expression of CRP and for C/EBP , NF-B , and STAT3 that contribute to regulation of expression of CRP during the acute phase response. Note that C/EBP and NF-B and the repressor OCT-1 utilize overlapping elements.

Treating And Preventing Elevated C

By Jillian Levy, CHHC

C-reactive protein levels increase and decrease depending on how much inflammation youre experiencing at any given time. Inflammation is defined as Redness, swelling, pain, and/or a feeling of heat in an area of the body. This is a protective reaction to injury, disease, or irritation of the tissues.

When you arent sick or injured, its normal for C-reactive protein levels to be low. But when something happens to signal to the body that it needs to be healed, levels rise to make this happen. Once you start to recover and symptoms subside, levels will fall and should return to normal.

This is why doctors use CRP tests to determine if a patients treatment plan is working, in addition to assessing if he/she is at risk for problems related to chronic inflammation , including heart disease.

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How Are Normal And Elevated C

C-reactive protein is a marker of inflammation and is typically not detected in the blood unless some degree of inflammation is present in the body.

  • CRP measurement is made using a blood sample from a vein. The sample is then taken to a laboratory and analyzed.
  • The traditional CRP measurement is often used to detect inflammation in the body. Your health-care provider may order a C-reactive protein level to check for flare-ups of inflammatory diseases such as rheumatoid arthritis, lupus, or vasculitis or to monitor whether anti-inflammatory medications are working to treat a disease or condition.
  • Currently, a more highly sensitive measurement to detect CRP is used for cardiovascular risk assessment. This high-sensitive C-reactive protein is termed hs-CRP.
  • Because measuring CRP levels at any point in time may be influenced by any infection or inflammation in the body, onetime measurement is generally not regarded as an adequate predictor of cardiovascular risk. Therefore, the U.S. Centers for Disease Control and Prevention recommends checking two separate CRP levels approximately two weeks apart and using the average number of the two readings for cardiovascular risk assessment and screening purposes.

Looking For Reference Ranges

Attempting To Further Reduce Biological Age: hs-CRP

You may be able to find your test results on your laboratorys website or patient portal. However, you are currently at Testing.com. You may have been directed here by your labs website in order to provide you with background information about the test you had performed. You will need to return to your labs website or portal, or contact your healthcare practitioner in order to obtain your test results.

Testing.com is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test to obtain the reference range.

For more information, please read the article Reference Ranges and What They Mean.

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When Should You Have C

Checking the CRP level for the entire adult population is not recommended. Some experts recommend checking the serum CRP level routinely along with the cholesterol level however, although this is not widely accepted. Ideally, for cardiac risk testing, it is advisable to use the average between two separate CRP levels drawn two weeks part.

More importantly, the CRP level can provide additional information about an individual’s cardiovascular risk in conjunction with other known cardiac risk factors, such as,

  • exercise, and
  • cholesterol-lowering medication.

People with elevated C-reactive protein levels may be advised by their treating doctors. Statin drugs are at the forefront of the recommended cholesterol-lowering agents. Lowering of CRP may be seen with the use of statin drugs even without significant improvement of the cholesterol profile.

Reduction of CRP level has also been noted in individuals with known cardiovascular disease who begin aspirin therapy. In those without known cardiovascular disease or significant risk factors for it, aspirin use is not generally recommended. Some diabetic medications have also been shown to reduce CRP levels in people with or without diabetes mellitus. This effect was seen independent of their glucose-lowering effects.

How Is The Test Used

A high-sensitivity C-reactive protein test measures low levels of CRP and may be used to help evaluate an individual for risk of cardiovascular disease . It may be used in combination with a lipid panel or with other cardiac risk markers, such as a lipoprotein-associated phospholipase A2 test, to provide added information about heart disease risk.

High-sensitivity CRP is thought by some experts to be a useful test for determining risk of CVD, heart attacks, and strokes and that hs-CRP can play a role in the evaluation process before a person develops one of these health problems. Some say that the best way to predict risk is to combine a good marker for inflammation, like hs-CRP, with the lipid panel. Several groups have recommended that this test be used for people who have a moderate risk of heart attack over the next 10 years.

However, not all health professionals agree on hs-CRPs usefulness. Clinical trials that involve measuring hs-CRP levels are currently underway in an effort to better understand its role in cardiovascular events. These studies will help to form and refine guidelines on its use in screening and treatment decisions.

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Meet The Protein That Measures Inflammation Levels

C-reactive protein or CRP is an inflammatory protein that is one of best ways to measure your inflammation levels. Produced mainly by the liver, we all make CRP and in normal levels CRP helps fight off infections and protect your body. You see, inflammation is not inherently bad but just like anything else in the bodylike hormones and bacteriainflammation is subject to the Goldilocks principle: It can’t be too high or too low it needs to be just right.

Inflammation becomes damaging when it flares unchecked, like a forest fire fueled by gasoline. The CRP test measures your inflammatory firestorm.

Crp And Heart Disease

Measuring Your C Reactive Protein Levels

American Heart Association in 2019 states that when considering all risk factors, people with CRP levels greater than or equal to 2 milligrams per liter may need more intense measures to prevent cardiovascular disease.

Elevated levels of CRP may have an important role in identifying people who might need closer follow-up or more intensive treatment after heart attacks or heart procedures.

CRP levels may also be useful in identifying people at risk of heart disease when cholesterol levels alone may not be helpful.

  • a diet low in nutrients and higher in fat and refined carbs
  • physical inactivity
  • overweight and obesity

A family history of heart disease can also put you at a higher risk of heart disease.

No special preparation is necessary for this test. You may eat normally on the day of, and the test can happen at any time of day.

This test is done via a blood sample, so there will be a small needle involved.

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When Is It Ordered

Currently, there is no consensus on when to get tested, though some guidelines include recommendations on hs-CRP testing. For example, a guideline from the American College of Cardiology Foundations and the American Heart Association says that hs-CRP testing may be useful when men 50 years old or younger and women 60 years old or younger have intermediate risk. It also may be useful for treatment decisions when men and women are older than these respective ages and have LDL-C less than 130 mg/L and meet several other criteria, such as no existing heart disease, diabetes, kidney disease, or inflammatory conditions.

When hs-CRP is evaluated, it may be repeated to confirm that a person has persistent low levels of inflammation. The CDC and the American Heart Association recommend that measurement of hs-CRP greater than 10 mg/L be repeated twice, optimally two weeks apart, fasting or non-fasting in patients free of infection or acute illness.

Yoga Tai Chi Qigong And Meditation

Yoga, Tai Chi, and Qi Gong are exercise therapies that integrate moderate physical activity, deep breathing, and meditation to promote stress reduction and relaxation, which can beneficially influence the immune system and overall health .

Studies suggest that 7 to 16 weeks of these mind-body therapies can cause significant improvements in CRP levels .

People who do them longer and persistently may reap better effects. When long-term expert hatha yoga practitioners and novices were compared in a study, expert practitioners had lower CRP levels .

However, even shorter interventions seem to be beneficial.

In one study, an 8-week regimen of yoga in addition to standard medical therapy significantly reduced CRP levels in patients with heart failure .

In another study, a gentle form of tai chi in patients with type 2 diabetes who were also obese decreased CRP levels .

Similarly, a decrease in CRP was also observed in older depressed participants receiving an SSRI when they also practiced tai chi .

In two studies with cancer patients, medical qigong lowered CRP levels, reduced the side effects of cancer, and improved the quality of life .

A practice of mindfulness in faculty members of Ohio State University who had elevated CRP helped decrease their CRP levels. Although not statistically significant, at 2-months the CRP level was on average 1 mg/ml lower a change that may have clinical significance .

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What Are The Causes Of Elevated C

Elevated CRP can signal many different conditions, including cancer, cardiovascular disease, infection, and autoimmune conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease. The chronic inflammation behind an elevated CRP level may also be influenced by genetics, a sedentary lifestyle, too much stress, and exposure to environmental toxins such as secondhand tobacco smoke. Diet has a huge impact, particularly one that contains a lot of refined, processed and manufactured foods.

What Is The Conventional Treatment Of Elevated C

Cardiovascular Inflammation: Why Not Just Do a CRP Test?

Conventional physicians may prescribe the same drugs used to lower LDL cholesterol to also lower levels of CRP. In addition, they will typically recommend exercise and weight loss where appropriate, since both can help lower CRP levels. In general, conventional physicians recommend the same lifestyle changes shown to reduce heart disease diet, exercise, not smoking, drinking less alcohol, following a heart-healthy diet to lower elevated C-reactive protein levels.

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Addressing Your Risk Factors

It is not known now much it helps to take steps aimed specifically at reducing your CRP levels.

Likewise, it is uncertain whether treatment aimed specifically at lowering CRP levels can reduce cardiovascular risk.

That aside, knowing your CRP levels are elevated should encourage you to take every opportunity to reduce your risk of heart disease.

Elevated CRP levels are almost always associated with other risk factors for heart disease, including:

Talk to your healthcare provider about your heart disease risk factors and what can be done to address them and your CRP levels.

This may involve habit changes, weight loss efforts, and/or medication.

Here’s How To Lower Your Crp

If your CRP levels are high, I recommend working with your doctor and a qualified functional medicine practitioner to find out what is causing your inflammation. Further testing and a comprehensive health history can uncover the pieces to your inflammation puzzle. Here are my top tips for bringing inflammation levels back down to normal:

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What Is The Difference Between Regular Crp And Hs

Both tests measure the same protein in the blood. The hs-CRP test is for apparently healthy people to determine their risk of cardiovascular disease. It measures CRP in the range from 0.5 to 10 mg/L. The CRP test is ordered to evaluate people who have signs and symptoms of a serious bacterial infection or of a serious chronic inflammatory disease such as rheumatoid arthritis. It measures CRP in the range from 10 to 1000 mg/L.

Normal And Critical Findings

High

Lab values vary, and there is no standard at present. However, in general, the result is reported in either mg/dL or mg/L. Hs-CRP is usually reported in mg/L. When used for cardiac risk stratification, hs-CRP levels less than 1 mg/L are considered low risk. Levels between 1 mg/L and 3 mg/L are considered a moderate risk and a level greater than 3 mg/L is considered high risk for the development of cardiovascular disease.

Interpretation of CRP levels:

Less than 0.3 mg/L: Normal .

0.3 to 1.0 mg/L: Normal or minor elevation .

1.0 to 10.0 mg/L: Moderate elevation .

More than 10.0 mg/L: Marked elevation .

More than 50.0 mg/L: Severe elevation .

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